List of enzymes




This page lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission [EC] numbering system. For a list of the EC numbers themselves, see:



  • List of EC numbers (EC 1)

  • List of EC numbers (EC 2)

  • List of EC numbers (EC 3)

  • List of EC numbers (EC 4)

  • List of EC numbers (EC 5)

  • List of EC numbers (EC 6)




Contents






  • 1 Category:Oxidoreductases (EC 1) (Oxidoreductase)


    • 1.1 Category:EC 1.1 (act on the CH-OH group of donors)


    • 1.2 Category:EC 1.2 (act on the aldehyde or oxo group of donors)


    • 1.3 Category:EC 1.3 (act on the CH-CH group of donors)


    • 1.4 Category:EC 1.4 (act on the CH-NH2 group of donors)


    • 1.5 Category:EC 1.5 (act on CH-NH group of donors)


    • 1.6 Category:EC 1.6 (act on NADH or NADPH)


    • 1.7 Category:EC 1.7 (act on other nitrogenous compounds as donors)


    • 1.8 Category:EC 1.8 (act on a sulfur group of donors)


    • 1.9 Category:EC 1.9 (act on a heme group of donors)


    • 1.10 Category:EC 1.10 (act on diphenols and related substances as donors)


    • 1.11 Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)


    • 1.12 Category:EC 1.12 (act on hydrogen as a donor)


    • 1.13 Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)


    • 1.14 Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)


    • 1.15 Category:EC 1.15 (act on superoxide radicals as acceptors)


    • 1.16 Category:EC 1.16 (oxidize metal ions)


    • 1.17 Category:EC 1.17 (act on CH or CH2 groups)


    • 1.18 Category:EC 1.18 (act on iron-sulfur proteins as donors)


    • 1.19 Category:EC 1.19 (act on reduced flavodoxin as donor)


    • 1.20 Category:EC 1.20 (act on phosphorus or arsenic as donors)


    • 1.21 Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)


    • 1.22 Category:EC 1.97 (other oxidoreductases)




  • 2 Category:Transferases (EC 2) (Transferase)


    • 2.1 Category:EC 2.1 (transfer one-carbon groups, Methylase)


    • 2.2 Category:EC 2.2 (transfer aldehyde or ketone groups)


    • 2.3 Category:EC 2.3 (acyltransferases)


    • 2.4 Category:EC 2.4 (glycosyltransferases)


    • 2.5 Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)


    • 2.6 Category:EC 2.6 (transfer nitrogenous groups)


    • 2.7 Category:EC 2.7 (transfer phosphorus-containing groups)


    • 2.8 Category:EC 2.8 (transfer sulfur-containing groups)


    • 2.9 Category:EC 2.9 (transfer selenium-containing groups)




  • 3 Category:Hydrolases (EC 3) (Hydrolase)


    • 3.1 Category:EC 3.1 (act on ester bonds)


    • 3.2 Category:EC 3.2 (act on sugars - glycosylases)


    • 3.3 Category:EC 3.3 (act on ether bonds)


    • 3.4 Category:EC 3.4 (act on peptide bonds - Peptidase)


    • 3.5 Category:EC 3.5 (act on carbon-nitrogen bonds, other than peptide bonds)


    • 3.6 Category:EC 3.6 (act on acid anhydrides)


    • 3.7 Category:EC 3.7 (act on carbon-carbon bonds)


    • 3.8 Category:EC 3.8 (act on halide bonds)


    • 3.9 Category:EC 3.9 (act on phosphorus-nitrogen bonds)


    • 3.10 Category:EC 3.10 (act on sulfur-nitrogen bonds)


    • 3.11 Category:EC 3.11 (act on carbon-phosphorus bonds)


    • 3.12 Category:EC 3.12 (act on sulfur-sulfur bonds)


    • 3.13 Category:EC 3.13 (act on carbon-sulfur bonds)




  • 4 Category:Lyases (EC 4) (Lyase)


    • 4.1 Category:EC 4.1 (carbon-carbon lyases)


    • 4.2 Category:EC 4.2 (carbon-oxygen lyases)


    • 4.3 Category:EC 4.3 (carbon-nitrogen lyases)


    • 4.4 Category:EC 4.4 (carbon-sulfur lyases)


    • 4.5 Category:EC 4.5 (carbon-halide lyases)


    • 4.6 Category:EC 4.6 (phosphorus-oxygen lyases)




  • 5 Category:Isomerases (EC 5) (Isomerase)


    • 5.1 Category:EC 5.1 (racemases and epimerases)


    • 5.2 Category:EC 5.2 (cis-trans-isomerases)


    • 5.3 Category:EC 5.3 (intramolecular oxidoreductases)


    • 5.4 Category:EC 5.4 (intramolecular transferases -- mutases)


    • 5.5 Category:EC 5.5 (intramolecular lyases)


    • 5.6 Category:EC 5.99 (other isomerases)




  • 6 Category:Ligases (EC 6) (Ligase)


    • 6.1 Category:EC 6.1 (form carbon-oxygen bonds)


    • 6.2 Category:EC 6.2 (form carbon-sulfur bonds)


    • 6.3 Category:EC 6.3 (form carbon-nitrogen bonds)


    • 6.4 Category:EC 6.4 (form carbon-carbon bonds)


    • 6.5 Category:EC 6.5 (form phosphoric ester bonds)


    • 6.6 Category:EC 6.6 (form nitrogen-metal bonds)







Category:Oxidoreductases (EC 1) (Oxidoreductase)



  • Dehydrogenase

  • Luciferase

  • DMSO reductase



Category:EC 1.1 (act on the CH-OH group of donors)




  • Category:EC 1.1.1 (with NAD+ or NADP+ as acceptor)


    • Alcohol dehydrogenase (NAD) EC 1.1.1.1


    • Alcohol dehydrogenase (NADP) EC 1.1.1.2


    • Homoserine dehydrogenase EC 1.1.1.3


    • Aminopropanol oxidoreductase EC 1.1.1.4


    • Diacetyl reductase EC 1.1.1.5


    • Glycerol dehydrogenase EC 1.1.1.6


    • Propanediol-phosphate dehydrogenase EC 1.1.1.7


    • glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8


    • D-xylulose reductase EC 1.1.1.9


    • L-xylulose reductase EC 1.1.1.10


    • Lactate dehydrogenase EC 1.1.1.27


    • Malate dehydrogenase EC 1.1.1.37


    • Isocitrate dehydrogenase EC 1.1.1.42


    • HMG-CoA reductase EC 1.1.1.88




  • Category:EC 1.1.2 (with a cytochrome as acceptor)


  • Category:EC 1.1.3 (with oxygen as acceptor)


    • Glucose oxidase EC 1.1.3.4


    • L-gulonolactone oxidase EC 1.1.3.8


    • Thiamine oxidase EC 1.1.3.23


    • Xanthine oxidase EC 1.1.3.32




  • Category:EC 1.1.4 (with a disulfide as acceptor)


  • Category:EC 1.1.5 (with a quinone or similar compound as acceptor)


  • Category:EC 1.1.99 (with other acceptors)



Category:EC 1.2 (act on the aldehyde or oxo group of donors)




  • Category:EC 1.2.1 (with NAD+ or NADP+ as acceptor)


    • Acetaldehyde dehydrogenase EC 1.2.1.10


    • Glyceraldehyde 3-phosphate dehydrogenase EC 1.2.1.12


    • Pyruvate dehydrogenase EC 1.2.1.51




  • Category:EC 1.2.4

    • Oxoglutarate dehydrogenase EC 1.2.4.2




Category:EC 1.3 (act on the CH-CH group of donors)




  • Category:EC 1.3.1 (with NAD+ or NADP+ as acceptor)

    • Biliverdin reductase EC 1.3.1.24



  • Category:EC 1.3.2 (with a cytochrome as acceptor)


  • Category:EC 1.3.3 (with oxygen as acceptor)

    • Protoporphyrinogen oxidase EC 1.3.3.4



  • Category:EC 1.3.5 (with a quinone or similar compound as acceptor)


  • Category:EC 1.3.7 (with an iron-sulfur protein as acceptor)


  • Category:EC 1.3.99 (with other acceptors)



Category:EC 1.4 (act on the CH-NH2 group of donors)



  • Category:EC 1.4.3

    • Monoamine oxidase EC 1.4.3.4



Category:EC 1.5 (act on CH-NH group of donors)




  • Category:EC 1.5.1 (with NAD+ or NADP+ as acceptor)


    • Dihydrofolate reductase EC 1.5.1.3


    • Methylenetetrahydrofolate reductase EC 1.5.1.20




  • Category:EC 1.5.3 (with oxygen as acceptor)


    • Sarcosine oxidase EC 1.5.3.1


    • Dihydrobenzophenanthridine oxidase EC 1.5.3.12




  • Category:EC 1.5.4 (with a disulfide as acceptor)


  • Category:EC 1.5.5 (with a quinone or similar compound as acceptor)


  • Category:EC 1.5.7 (with an iron-sulfur protein as acceptor)


  • Category:EC 1.5.8 (with a flavin as acceptor)


  • Category:EC 1.5.99 (with other acceptors)



Category:EC 1.6 (act on NADH or NADPH)




  • Category:EC 1.6.1 (with NAD+ or NADP+ as acceptor)


  • Category:EC 1.6.2 (with a cytochrome as acceptor)


  • Category:EC 1.6.3 (with oxygen as acceptor)


  • Category:EC 1.6.4 now Category:EC 1.8.1


  • Category:EC 1.6.5 (with a quinone or similar compound as acceptor)

    • NADH dehydrogenase EC 1.6.5.3



  • Category:EC 1.6.6 (with a nitrogenous group as acceptor)


  • Category:EC 1.6.7 now Category:EC 1.18.1


  • Category:EC 1.6.8 now Category:EC 1.5.1


  • Category:EC 1.6.99 (with other acceptors)



Category:EC 1.7 (act on other nitrogenous compounds as donors)




  • Category:EC 1.7.1 (with NAD+ or NADP+ as acceptor)


  • Category:EC 1.7.2 (with a cytochrome as acceptor)


  • Category:EC 1.7.3 (with oxygen as acceptor)

    • Urate oxidase EC 1.7.3.3



  • Category:EC 1.7.7 (with an iron-sulfur protein as acceptor)


  • Category:EC 1.7.99 (with other acceptors)


    • Nitrite reductase EC 1.7.99.3


    • Nitrate reductase EC 1.7.99.4





Category:EC 1.8 (act on a sulfur group of donors)




  • Category:EC 1.8.1 (with NAD+ or NADP+ as acceptor)


    • Glutathione reductase EC 1.8.1.7


    • Thioredoxin reductase EC 1.8.1.9




  • Category:EC 1.8.2 (with a cytochrome as acceptor)


  • Category:EC 1.8.3 (with oxygen as acceptor)

    • Sulfite oxidase EC 1.8.3.1



  • Category:EC 1.8.4 (with a disulfide as acceptor)


  • Category:EC 1.8.5 (with a quinone or similar compound as acceptor)


  • Category:EC 1.8.6 deleted, included in EC 2.5.1.18


  • Category:EC 1.8.7 (with an iron-sulfur protein as acceptor)


  • Category:EC 1.8.98 (with other, known, acceptors)


  • Category:EC 1.8.99 (with other acceptors)



Category:EC 1.9 (act on a heme group of donors)




  • Category:EC 1.9.3 (with oxygen as acceptor)

    • Cytochrome c oxidase EC 1.9.3.1



  • Category:EC 1.9.6 (with a nitrogenous as acceptor)


  • Category:EC 1.9.99 transferred, now EC 1.9.98.1



Category:EC 1.10 (act on diphenols and related substances as donors)




  • Category:EC 1.10.1(with NAD+ or NADP+ as acceptor)


  • Category:EC 1.10.2 (with a cytochrome as acceptor)

    • Coenzyme Q - cytochrome c reductase EC 1.10.2.2



  • Category:EC 1.10.3 (with oxygen as acceptor)


    • Catechol oxidase EC 1.10.3.1


    • Laccase EC 1.10.3.2




  • Category:EC 1.10.99 (with other acceptors)



Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)



  • Category:EC 1.11.1 (peroxidases)


    • Cytochrome c peroxidase EC 1.11.1.5


    • Catalase EC 1.11.1.6


    • Myeloperoxidase EC 1.11.1.7


    • Thyroid peroxidase EC 1.11.1.8


    • Glutathione peroxidase EC 1.11.1.9




Category:EC 1.12 (act on hydrogen as a donor)




  • Category:EC 1.12.1 (with NAD+ or NADP+ as acceptor)


  • Category:EC 1.12.2 (with a cytochrome as acceptor)


  • Category:EC 1.12.5 (with a quinone or similar compound as acceptor)


  • Category:EC 1.12.7 (with an iron-sulfur protein as acceptor)


  • Category:EC 1.12.98 (with other known acceptors)


  • Category:EC 1.12.99 (with other acceptors)



Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)




  • Category:EC 1.13.11 (With incorporation of two atoms of oxygen)

    • 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)



  • Category:EC 1.13.12 (With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases))


    • Renilla-luciferin 2-monooxygenase EC 1.13.12.5


    • Cypridina-luciferin 2-monooxygenase EC 1.13.12.6


    • Firefly luciferase EC 1.13.12.7


    • Watasenia-luciferin 2-monooxygenase EC 1.13.12.8


    • Oplophorus-luciferin 2-monooxygenase EC 1.13.12.13





Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)



  • Cytochrome P450 oxidase


  • Category:Cytochrome P450


    • Aromatase EC 1.14.14.1


    • CYP2D6 EC 1.14.14.1


    • CYP2E1 EC 1.14.14.1


    • CYP3A4 EC 1.14.14.1

    • Cytochrome P450 oxidase




  • Category:EC 1.14.12
    • Nitric oxide dioxygenase



  • Category:EC 1.14.13

    • Nitric oxide synthase EC 1.14.13.39



  • Category:EC 1.14.14


    • Aromatase EC 1.14.14.1


    • CYP2D6 EC 1.14.14.1


    • CYP2E1 EC 1.14.14.1


    • CYP3A4 EC 1.14.14.1




  • Category:EC 1.14.16

    • Phenylalanine hydroxylase EC 1.14.16.1



  • Category:EC 1.14.18

    • Tyrosinase EC 1.14.18.1




Category:EC 1.15 (act on superoxide radicals as acceptors)



  • Category:EC 1.15.1

    • Superoxide dismutase EC 1.15.1.1



Category:EC 1.16 (oxidize metal ions)



  • Category:EC 1.16.3

    • Ceruloplasmin EC 1.16.3.1



Category:EC 1.17 (act on CH or CH2 groups)




  • Category:EC 1.17.1


    • Leucoanthocyanidin reductase EC 1.17.1.3


    • Xanthine dehydrogenase EC 1.17.1.4


    • Nicotinate dehydrogenase EC 1.17.1.5


    • 4-hydroxy-tetrahydrodipicolinate reductase EC 1.17.1.8




  • Category:EC 1.17.2

    • Nicotinate dehydrogenase (cytochrome) EC 1.17.2.1



  • Category:EC 1.17.3

    • Xanthine oxidase EC 1.17.3.2



  • Category:EC 1.17.4


    • Ribonucleotide reductase EC 1.17.4.1


    • Ribonucleoside-triphosphate reductase EC 1.17.4.2

    • Vitamin K epoxide reductase


    • Vitamin-K-epoxide reductase (warfarin-sensitive) EC 1.17.4.4


    • Vitamin-K-epoxide reductase (warfarin-insensitive) EC 1.17.4.5

    • RRM1

    • RRM2

    • RRM2B




  • Category:EC 1.17.5

    • Caffeine dehydrogenase EC 1.17.5.2


  • Category:EC 1.17.7

  • Category:EC 1.17.99



Category:EC 1.18 (act on iron-sulfur proteins as donors)



  • Category:EC 1.18.6

    • Nitrogenase EC 1.18.6.1



Category:EC 1.19 (act on reduced flavodoxin as donor)



  • Category:EC 1.19.6

    • Nitrogenase (flavodoxin) EC 1.19.6.1



Category:EC 1.20 (act on phosphorus or arsenic as donors)



  • Category:EC 1.20.1

  • Category:EC 1.20.2


  • Category:EC 1.20.4


    • Arsenate reductase (glutaredoxin) EC 1.20.4.1

    • Glutaredoxin



  • Category:EC 1.20.9

  • Category:EC 1.20.99



Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)




  • Category:EC 1.21.1

    • Iodotyrosine deiodinase EC 1.21.1.1



  • Category:EC 1.21.3


    • Isopenicillin N synthase EC 1.21.3.1


    • Tetrahydrocannabinolic acid synthase EC 1.21.3.7



  • Category:EC 1.21.4


  • Category:EC 1.21.99


    • Thyroxine 5-deiodinase EC 1.21.99.3


    • Iodothyronine deiodinase EC 1.21.99.3 and EC 1.21.99.4





Category:EC 1.97 (other oxidoreductases)



  • Category:EC 1.97.1

    • Deiodinase EC 1.97.1.10



Category:Transferases (EC 2) (Transferase)


  • Glutathione S-transferase


Category:EC 2.1 (transfer one-carbon groups, Methylase)




  • Category:EC 2.1.1


    • Catechol-O-methyl transferase EC 2.1.1.6


    • DNA methyltransferase EC 2.1.1.72, EC 2.1.1.113, EC 2.1.1.37


    • Histone methyltransferase EC 2.1.1.43, EC 2.1.1.125




  • Category:EC 2.1.3


    • Aspartate transcarbamoylase EC 2.1.3.2


    • Ornithine transcarbamoylase EC 2.1.3.3





Category:EC 2.2 (transfer aldehyde or ketone groups)



  • Category:EC 2.2.1


    • Transketolase EC 2.2.1.1


    • Transaldolase EC 2.2.1.2


    • Acetolactate synthase EC 2.2.1.6


    • 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase EC 2.2.1.9




Category:EC 2.3 (acyltransferases)




  • Category:EC 2.3.1


    • Aminolevulinic acid synthase EC 2.3.1.37


    • Choline acetyltransferase EC 2.3.1.6




  • Category:EC 2.3.2


    • Factor XIII EC 2.3.2.13


    • Gamma glutamyl transpeptidase EC 2.3.2.2


    • Transglutaminase EC 2.3.2.13





Category:EC 2.4 (glycosyltransferases)



  • Category:EC 2.4.2

    • Hypoxanthine-guanine phosphoribosyltransferase EC 2.4.2.8


Category:EC 2.5



  • Category:EC 2.5.1

    • Thiaminase EC 2.5.1.2



Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)



    • Flavin prenyltransferase EC 2.5.1.129


Category:EC 2.6 (transfer nitrogenous groups)



  • Category:EC 2.6.1


    • Alanine transaminase EC 2.6.1.2


    • Aspartate transaminase EC 2.6.1.1




Category:EC 2.7 (transfer phosphorus-containing groups)



  • Category:EC 2.7.2

    • Butyrate kinase (EC 2.7.2.7)



Category:EC 2.8 (transfer sulfur-containing groups)




  • EC 2.8.1.1: Thiosulfate sulfurtransferase


  • EC 2.8.1.2: 3-mercaptopyruvate sulfurtransferase


  • EC 2.8.1.3: Thiosulfate--thiol sulfurtransferase


  • EC 2.8.1.4: tRNA uracil 4-sulfurtransferase


  • EC 2.8.1.5: Thiosulfate--dithiol sulfurtransferase


  • EC 2.8.1.6: Biotin synthase


  • EC 2.8.1.7: Cysteine desulfurase


  • EC 2.8.1.8: Lipoyl synthase


  • EC 2.8.1.9: Molybdenum cofactor sulfurtransferase


  • EC 2.8.1.10: Thiazole synthase


  • EC 2.8.1.11: Molybdopterin synthase sulfurtransferase


  • EC 2.8.1.12: Molybdopterin synthase


  • EC 2.8.1.13: tRNA-uridine 2-sulfurtransferase


  • EC 2.8.1.14: tRNA-5-taurinomethyluridine 2-sulfurtransferase


  • EC 2.8.1.15: tRNA-5-methyluridine(54) 2-sulfurtransferase



Category:EC 2.9 (transfer selenium-containing groups)




  • EC 2.9.1.1: L-seryl-tRNA(Sec) selenium transferase


  • EC 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase



Category:Hydrolases (EC 3) (Hydrolase)


  • Hydrolytic enzyme


Category:EC 3.1 (act on ester bonds)



  • Nuclease

  • Endonuclease

  • Exonuclease


  • Category:EC 3.1.1

    • Acid hydrolase


    • Phospholipase A (EC 3.1.1.4)


    • Acetylcholinesterase (EC 3.1.1.7)


    • Cholinesterase (EC 3.1.1.8)


    • Lipoprotein lipase (EC 3.1.1.34)




  • Category:EC 3.1.2

    • Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15)



  • Category:EC 3.1.3

    • Phosphatase


    • Alkaline phosphatase (EC 3.1.3.1)


    • Fructose bisphosphatase (EC 3.1.3.11)




  • Category:EC 3.1.4


    • Phospholipase C (EC 3.1.4.3)


    • CGMP specific phosphodiesterase type 5 (EC 3.1.4.17)


    • Phospholipase D (EC 3.1.4.50)




  • Category:EC 3.1.21


    • Restriction enzyme Type 1 (EC 3.1.21.3)


    • Restriction enzyme Type 2 (EC 3.1.21.4)


    • Restriction enzyme Type 3 (EC 3.1.21.5)


    • Restriction enzyme Type 4 (?)


    • Deoxyribonuclease I (EC 3.1.21.1)




  • Category:EC 3.1.26

    • RNase H (EC 3.1.26.4)



  • Category:EC 3.1.27
    • Ribonuclease




Category:EC 3.2 (act on sugars - glycosylases)



  • Category:EC 3.2.1


    • Amylase (EC 3.2.1.1)


    • Sucrase (EC 3.2.1.10)


    • Chitinase (EC 3.2.1.14)


    • Lysozyme (EC 3.2.1.17)


    • Maltase (EC 3.2.1.20)


    • Lactase (EC 3.2.1.23)


    • Beta-galactosidase (EC 3.2.1.23)


    • Hyaluronidase (EC 3.2.1.35)




Category:EC 3.3 (act on ether bonds)



  • Category:EC 3.3

  • Adenosylmethionine hydrolase

  • S-adenosyl-L-homocysteine hydrolase

  • Alkenylglycerophosphocholine hydrolase

  • Alkenylglycerophosphoethanolamine hydrolase

  • Cholesterol-5,6-oxide hydrolase

  • Hepoxilin-epoxide hydrolase

  • Isochorismatase

  • Leukotriene-A4 hydrolase

  • Limonene-1,2-epoxide hydrolase

  • Microsomal epoxide hydrolase

  • Trans-epoxysuccinate hydrolase



Category:EC 3.4 (act on peptide bonds - Peptidase)




  • Category:EC 3.4.11
    • Alanine aminopeptidase



  • Category:EC 3.4.15
    • Angiotensin converting enzyme



  • Category:EC 3.4.21

    • Serine protease


    • Chymotrypsin (EC 3.4.21.1)


    • Trypsin (EC 3.4.21.4)


    • Thrombin (EC 3.4.21.5)


    • Factor X (EC 3.4.21.6)


    • Plasmin (EC 3.4.21.7)


    • Acrosin (EC 3.4.21.10)


    • Factor VII (EC 3.4.21.21)


    • Factor IX (EC 3.4.21.22)


    • Prolyl oligopeptidase (EC 3.4.21.26)


    • Factor XI (EC 3.4.21.27)


    • Elastase (EC 3.4.21.37)


    • Factor XII (EC 3.4.21.38)


    • Proteinase K (EC 3.4.21.64)


    • Tissue plasminogen activator (EC 3.4.21.68)


    • Protein C (EC 3.4.21.69)




  • Category:EC 3.4.22

    • Separase (EC 3.4.22.49)



  • Category:EC 3.4.23


    • Pepsin (EC 3.4.23.1)


    • Rennet (EC 3.4.23.4)


    • Renin (EC 3.4.23.15)


    • Trypsinogen (EC 3.4.23.18) and (20/21/23/24/26)


    • Plasmepsin (EC 3.4.23.39)




  • Category:EC 3.4.24

    • Matrix metalloproteinase (EC 3.4.24.7)



  • Category:EC 3.4.25
    • Metalloendopeptidase




Category:EC 3.5 (act on carbon-nitrogen bonds, other than peptide bonds)




  • Category:EC 3.5.1 (In linear amides)

    • Urease (EC 3.5.1.5)



  • Category:EC 3.5.2 (In cyclic amides)

    • Beta-lactamase (EC 3.5.2.6)



  • Category:EC 3.5.3 (In linear amidines)

    • Arginase (EC 3.5.3.1)



  • Category:EC 3.5.4 (In cyclic amidines)


    • Adenosine deaminase (EC 3.5.4.4)


    • GTP cyclohydrolase I (EC 3.5.4.16)




  • Category:EC 3.5.5 (In nitriles)

    • Nitrilase (EC 3.5.5.1)




Category:EC 3.6 (act on acid anhydrides)




  • Category:EC 3.6.1

    • Helicase

    • DnaB helicase

    • RecQ helicase




  • Category:EC 3.6.3

    • ATPase


    • NaKATPase (EC 3.6.3.9)


    • ATP synthase (EC 3.6.3.14)





Category:EC 3.7 (act on carbon-carbon bonds)



  • Kynureninase EC 3.7.1.3


Category:EC 3.8 (act on halide bonds)


  • EC 3.8.1.3 Haloacetate dehalogenase


Category:EC 3.9 (act on phosphorus-nitrogen bonds)




  • EC 3.9.1.1: Phosphoamidase


  • EC 3.9.1.2: Protein arginine phosphatase


  • EC 3.9.1.3: Phosphohistidine phosphatase



Category:EC 3.10 (act on sulfur-nitrogen bonds)




  • EC 3.10.1.1: N-sulfoglucosamine sulfohydrolase


  • EC 3.10.1.2: Cyclamate sulfohydrolase



Category:EC 3.11 (act on carbon-phosphorus bonds)




  • EC 3.11.1.1: Phosphonoacetaldehyde hydrolase


  • EC 3.11.1.2: Phosphonoacetate hydrolase


  • EC 3.11.1.3: Phosphonopyruvate hydrolase



Category:EC 3.12 (act on sulfur-sulfur bonds)



  • EC 3.12.1.1: Trithionate hydrolase


Category:EC 3.13 (act on carbon-sulfur bonds)




  • EC 3.13.1.1: UDP-sulfoquinovose synthase


  • EC 3.13.1.3: 2'-hydroxybiphenyl-2-sulfinate desulfinase


  • EC 3.13.1.4: 3-sulfinopropanoyl-CoA desulfinase


  • EC 3.13.1.5: Carbon disulfide hydrolase


  • EC 3.13.1.6: [[[CysO sulfur-carrier protein]-S-L-cysteine hydrolase]]


  • EC 3.13.1.7: Carbonyl sulfide hydrolase


  • EC 3.13.1.8: S-adenosyl-L-methionine hydrolase (adenosine-forming)



Category:Lyases (EC 4) (Lyase)



Category:EC 4.1 (carbon-carbon lyases)



  • Category:EC 4.1.1


    • Ornithine decarboxylase (EC 4.1.1.17)


    • Uridine monophosphate synthetase (EC 4.1.1.23)


    • Aromatic-L-amino-acid decarboxylase (EC 4.1.1.28)


    • RubisCO (EC 4.1.1.39)




  • Category:EC 4.1.2

    • Fructose-bisphosphate aldolase (EC 4.1.2.13)



Category:EC 4.2 (carbon-oxygen lyases)



  • Category:EC 4.2.1


    • Carbonic anhydrase (EC 4.2.1.1)


    • Tryptophan synthase (EC 4.2.1.20)




Category:EC 4.3 (carbon-nitrogen lyases)



  • Category:EC 4.3.1

    • Phenylalanine ammonia-lyase (EC 4.3.1.24)



Category:EC 4.4 (carbon-sulfur lyases)



  • Category:EC 4.4.1

    • Cystathionine gamma-lyase

    • Cystathionine beta-lyase

    • Leukotriene C4 synthase




Category:EC 4.5 (carbon-halide lyases)



  • Category:EC 4.5.1

    • Dichloromethane dehalogenase

    • Halohydrin dehalogenase




Category:EC 4.6 (phosphorus-oxygen lyases)



  • Category:EC 4.6.1


    • Adenylate cyclase (EC 4.6.1.1)


    • Guanylate cyclase (EC 4.6.1.2)




Category:Isomerases (EC 5) (Isomerase)



Category:EC 5.1 (racemases and epimerases)



  • Category:EC 5.1.1


  • Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)

  • Serine racemase

  • Category:EC 5.1.2

  • Mandelate racemase

  • Category:EC 5.1.3

  • UDP-glucose 4-epimerase

  • Category:EC 5.1.99

  • Methylmalonyl CoA epimerase



Category:EC 5.2 (cis-trans-isomerases)



  • Category:EC 5.2


  • FKBP: FKBP1A

  • FKBP1B

  • FKBP2

  • FKBP3

  • FKBP5

  • FKBP6

  • FKBP8

  • FKBP9

  • FKBP10

  • FKBP52

  • FKBPL

  • Cyclophilin

  • Parvulin

  • Prolyl isomerase

  • 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase

  • Beta-carotene isomerase

  • Farnesol 2-isomerase

  • Furylfuramide isomerase

  • Linoleate isomerase

  • Maleate isomerase

  • Maleylacetoacetate isomerase

  • Maleylpyruvate isomerase

  • Parvulin

  • Photoisomerase

  • Prolycopene isomerase

  • Prolyl isomerase

  • Retinal isomerase

  • Retinol isomerase

  • Zeta-carotene isomerase



Category:EC 5.3 (intramolecular oxidoreductases)




  • Category:EC 5.3.3

    • Enoyl CoA isomerase (EC 5.3.3.8)



  • Category:EC 5.3.4

    • Protein disulfide isomerase (EC 5.3.4.1)




Category:EC 5.4 (intramolecular transferases -- mutases)



  • Category:EC 5.4.2

    • Phosphoglucomutase (EC 5.4.2.2)



Category:EC 5.5 (intramolecular lyases)






































































































Intramolecular lyases:
EC number
Examples
EC 5.5.1.1
Muconate cycloisomerase
EC 5.5.1.2
3-carboxy-cis,cis-muconate cycloisomerase
EC 5.5.1.3
Tetrahydroxypteridine cycloisomerase
EC 5.5.1.4
Inositol-3-phosphate synthase
EC 5.5.1.5
Carboxy-cis,cis-muconate cyclase
EC 5.5.1.6
Chalcone isomerase
EC 5.5.1.7
Chloromuconate cycloisomerase
EC 5.5.1.8
(+)-bornyl diphosphate synthase
EC 5.5.1.9
Cycloeucalenol cycloisomerase
EC 5.5.1.10
Alpha-pinene-oxide decyclase
EC 5.5.1.11
Dichloromuconate cycloisomerase
EC 5.5.1.12
Copalyl diphosphate synthase
EC 5.5.1.13
Ent-copalyl diphosphate synthase
EC 5.5.1.14
Syn-copalyl-diphosphate synthase
EC 5.5.1.15
Terpentedienyl-diphosphate synthase
EC 5.5.1.16
Halimadienyl-diphosphate synthase
EC 5.5.1.17
(S)-beta-macrocarpene synthase
EC 5.5.1.18
Lycopene epsilon-cyclase
EC 5.5.1.19
Lycopene beta-cyclase
EC 5.5.1.20
Prosolanapyrone-III cycloisomerase
EC 5.5.1.n1 D-ribose pyranase
EC 5.5.1.22
Steroid Delta Isomerase




Category:EC 5.99 (other isomerases)



  • Category:EC 5.99.1

    • Topoisomerase (type I: EC 5.99.1.2, type II: EC 5.99.1.3)



Category:Ligases (EC 6) (Ligase)



Category:EC 6.1 (form carbon-oxygen bonds)


6-carboxytetrahydropterin synthase



  • Category:EC 6.1.1

    • FARSB (EC 6.1.1.20)



Category:EC 6.2 (form carbon-sulfur bonds)




  • EC 6.2.1.1: Acetate--CoA ligase


  • EC 6.2.1.2: Medium-chain acyl-CoA ligase


  • EC 6.2.1.3: Long-chain-fatty-acid--CoA ligase


  • EC 6.2.1.4: Succinate--CoA ligase (GDP-forming)


  • EC 6.2.1.5: Succinate--CoA ligase (ADP-forming)


  • EC 6.2.1.6: Glutarate--CoA ligase


  • EC 6.2.1.7: Cholate--CoA ligase


  • EC 6.2.1.8: Oxalate--CoA ligase


  • EC 6.2.1.9: Malate--CoA ligase


  • EC 6.2.1.10: Acid--CoA ligase (GDP-forming)


  • EC 6.2.1.11: Biotin--CoA ligase


  • EC 6.2.1.12: 4-coumarate--CoA ligase


  • EC 6.2.1.13: Acetate--CoA ligase (ADP-forming)


  • EC 6.2.1.14: 6-carboxyhexanoate--CoA ligase


  • EC 6.2.1.15: Arachidonate--CoA ligase


  • EC 6.2.1.16: Acetoacetate--CoA ligase


  • EC 6.2.1.17: Propionate--CoA ligase


  • EC 6.2.1.18: Citrate--CoA ligase


  • EC 6.2.1.19: Long-chain-fatty-acid--protein ligase


  • EC 6.2.1.20: [[Long-chain-fatty-acid--[acyl-carrier-protein] ligase]]


  • EC 6.2.1.21: Transferred entry: 6.2.1.30


  • EC 6.2.1.22: [[[Citrate (pro-3S)-lyase] ligase]]


  • EC 6.2.1.23: Dicarboxylate--CoA ligase


  • EC 6.2.1.24: Phytanate--CoA ligase


  • EC 6.2.1.25: Benzoate--CoA ligase


  • EC 6.2.1.26: o-succinylbenzoate--CoA ligase


  • EC 6.2.1.27: 4-hydroxybenzoate--CoA ligase


  • EC 6.2.1.28: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate--CoA ligase


  • EC 6.2.1.29: Transferred entry: 6.2.1.7


  • EC 6.2.1.30: Phenylacetate--CoA ligase


  • EC 6.2.1.31: 2-furoate--CoA ligase


  • EC 6.2.1.32: Anthranilate--CoA ligase


  • EC 6.2.1.33: 4-chlorobenzoate--CoA ligase


  • EC 6.2.1.34: Trans-feruloyl-CoA synthase


  • EC 6.2.1.35: [[Acetate--[acyl-carrier protein] ligase]]


  • EC 6.2.1.36: 3-hydroxypropionyl-CoA synthase


  • EC 6.2.1.37: 3-hydroxybenzoate--CoA ligase


  • EC 6.2.1.38: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase


  • EC 6.2.1.39: [[[Butirosin acyl-carrier protein]--L-glutamate ligase]]


  • EC 6.2.1.40: 4-hydroxybutyrate--CoA ligase


  • EC 6.2.1.41: 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate--CoA ligase


  • EC 6.2.1.42: 3-oxocholest-4-en-26-oate--CoA ligase


  • EC 6.2.1.43: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase


  • EC 6.2.1.44: 3-(methylthio)propionyl--CoA ligase


  • EC 6.2.1.45: E1 ubiquitin-activating enzyme


  • EC 6.2.1.46: [[L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase]]


  • EC 6.2.1.47: Medium-chain-fatty-acid--(acyl-carrier-protein) ligase


  • EC 6.2.1.48: Carnitine--CoA ligase


  • EC 6.2.1.49: Long-chain fatty acid adenylyltransferase FadD28


  • EC 6.2.1.50: 4-hydroxybenzoate adenylyltransferase FadD22


  • EC 6.2.1.51: 4-hydroxyphenylalkanoate adenylyltransferase FadD29


  • EC 6.2.1.52: L-firefly luciferin--CoA ligase


  • EC 6.2.1.53: [[L-proline--[L-prolyl-carrier protein] ligase]]


  • EC 6.2.1.54: [[D-alanine--[D-alanyl-carrier protein] ligase]]


  • EC 6.2.1.55: [[E1 SAMP-activating enzyme]



Category:EC 6.3 (form carbon-nitrogen bonds)




  • Glutamine synthetase (EC 6.3.1.2)


  • Argininosuccinate synthetase (EC 6.3.4.5)


  • CTP synthase (EC 6.3.4.2)



Category:EC 6.4 (form carbon-carbon bonds)




  • Pyruvate carboxylase (EC 6.4.1.1)


  • Acetyl-CoA carboxylase (EC 6.4.1.2)



Category:EC 6.5 (form phosphoric ester bonds)


DNA ligase (EC 6.5.1.1)



Category:EC 6.6 (form nitrogen-metal bonds)








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