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This page lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission [EC] numbering system. For a list of the EC numbers themselves, see:

List of EC numbers (EC 1)

List of EC numbers (EC 2)

List of EC numbers (EC 3)

List of EC numbers (EC 4)

List of EC numbers (EC 5)

List of EC numbers (EC 6)

1 Category:Oxidoreductases (EC 1) (Oxidoreductase)
- 1.1 Category:EC 1.1 (act on the CH-OH group of donors)
- 1.2 Category:EC 1.2 (act on the aldehyde or oxo group of donors)
- 1.3 Category:EC 1.3 (act on the CH-CH group of donors)
- 1.4 Category:EC 1.4 (act on the CH-NH₂ group of donors)
- 1.5 Category:EC 1.5 (act on CH-NH group of donors)
- 1.6 Category:EC 1.6 (act on NADH or NADPH)
- 1.7 Category:EC 1.7 (act on other nitrogenous compounds as donors)
- 1.8 Category:EC 1.8 (act on a sulfur group of donors)
- 1.9 Category:EC 1.9 (act on a heme group of donors)
- 1.10 Category:EC 1.10 (act on diphenols and related substances as donors)
- 1.11 Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)
- 1.12 Category:EC 1.12 (act on hydrogen as a donor)
- 1.13 Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)
- 1.14 Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)
- 1.15 Category:EC 1.15 (act on superoxide radicals as acceptors)
- 1.16 Category:EC 1.16 (oxidize metal ions)
- 1.17 Category:EC 1.17 (act on CH or CH₂ groups)
- 1.18 Category:EC 1.18 (act on iron-sulfur proteins as donors)
- 1.19 Category:EC 1.19 (act on reduced flavodoxin as donor)
- 1.20 Category:EC 1.20 (act on phosphorus or arsenic as donors)
- 1.21 Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)
- 1.22 Category:EC 1.97 (other oxidoreductases)

2 Category:Transferases (EC 2) (Transferase)
- 2.1 Category:EC 2.1 (transfer one-carbon groups, Methylase)
- 2.2 Category:EC 2.2 (transfer aldehyde or ketone groups)
- 2.3 Category:EC 2.3 (acyltransferases)
- 2.4 Category:EC 2.4 (glycosyltransferases)
- 2.5 Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)
- 2.6 Category:EC 2.6 (transfer nitrogenous groups)
- 2.7 Category:EC 2.7 (transfer phosphorus-containing groups)
- 2.8 Category:EC 2.8 (transfer sulfur-containing groups)
- 2.9 Category:EC 2.9 (transfer selenium-containing groups)

3 Category:Hydrolases (EC 3) (Hydrolase)
- 3.1 Category:EC 3.1 (act on ester bonds)
- 3.2 Category:EC 3.2 (act on sugars - glycosylases)
- 3.3 Category:EC 3.3 (act on ether bonds)
- 3.4 Category:EC 3.4 (act on peptide bonds - Peptidase)
- 3.5 Category:EC 3.5 (act on carbon-nitrogen bonds, other than peptide bonds)
- 3.6 Category:EC 3.6 (act on acid anhydrides)
- 3.7 Category:EC 3.7 (act on carbon-carbon bonds)
- 3.8 Category:EC 3.8 (act on halide bonds)
- 3.9 Category:EC 3.9 (act on phosphorus-nitrogen bonds)
- 3.10 Category:EC 3.10 (act on sulfur-nitrogen bonds)
- 3.11 Category:EC 3.11 (act on carbon-phosphorus bonds)
- 3.12 Category:EC 3.12 (act on sulfur-sulfur bonds)
- 3.13 Category:EC 3.13 (act on carbon-sulfur bonds)

4 Category:Lyases (EC 4) (Lyase)
- 4.1 Category:EC 4.1 (carbon-carbon lyases)
- 4.2 Category:EC 4.2 (carbon-oxygen lyases)
- 4.3 Category:EC 4.3 (carbon-nitrogen lyases)
- 4.4 Category:EC 4.4 (carbon-sulfur lyases)
- 4.5 Category:EC 4.5 (carbon-halide lyases)
- 4.6 Category:EC 4.6 (phosphorus-oxygen lyases)

5 Category:Isomerases (EC 5) (Isomerase)
- 5.1 Category:EC 5.1 (racemases and epimerases)
- 5.2 Category:EC 5.2 (cis-trans-isomerases)
- 5.3 Category:EC 5.3 (intramolecular oxidoreductases)
- 5.4 Category:EC 5.4 (intramolecular transferases -- mutases)
- 5.5 Category:EC 5.5 (intramolecular lyases)
- 5.6 Category:EC 5.99 (other isomerases)

6 Category:Ligases (EC 6) (Ligase)
- 6.1 Category:EC 6.1 (form carbon-oxygen bonds)
- 6.2 Category:EC 6.2 (form carbon-sulfur bonds)
- 6.3 Category:EC 6.3 (form carbon-nitrogen bonds)
- 6.4 Category:EC 6.4 (form carbon-carbon bonds)
- 6.5 Category:EC 6.5 (form phosphoric ester bonds)
- 6.6 Category:EC 6.6 (form nitrogen-metal bonds)

Category:Oxidoreductases (EC 1) (Oxidoreductase)

Dehydrogenase

Luciferase

DMSO reductase

Category:EC 1.1 (act on the CH-OH group of donors)

Category:EC 1.1.1 (with NAD⁺ or NADP⁺ as acceptor)
- Alcohol dehydrogenase (NAD) EC 1.1.1.1
- Alcohol dehydrogenase (NADP) EC 1.1.1.2
- Homoserine dehydrogenase EC 1.1.1.3
- Aminopropanol oxidoreductase EC 1.1.1.4
- Diacetyl reductase EC 1.1.1.5
- Glycerol dehydrogenase EC 1.1.1.6
- Propanediol-phosphate dehydrogenase EC 1.1.1.7
- glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8
- D-xylulose reductase EC 1.1.1.9
- L-xylulose reductase EC 1.1.1.10
- Lactate dehydrogenase EC 1.1.1.27
- Malate dehydrogenase EC 1.1.1.37
- Isocitrate dehydrogenase EC 1.1.1.42
- HMG-CoA reductase EC 1.1.1.88

Category:EC 1.1.2 (with a cytochrome as acceptor)

Category:EC 1.1.3 (with oxygen as acceptor)
- Glucose oxidase EC 1.1.3.4
- L-gulonolactone oxidase EC 1.1.3.8
- Thiamine oxidase EC 1.1.3.23
- Xanthine oxidase EC 1.1.3.32

Category:EC 1.1.4 (with a disulfide as acceptor)

Category:EC 1.1.5 (with a quinone or similar compound as acceptor)

Category:EC 1.1.99 (with other acceptors)

Category:EC 1.2 (act on the aldehyde or oxo group of donors)

Category:EC 1.2.1 (with NAD⁺ or NADP⁺ as acceptor)
- Acetaldehyde dehydrogenase EC 1.2.1.10
- Glyceraldehyde 3-phosphate dehydrogenase EC 1.2.1.12
- Pyruvate dehydrogenase EC 1.2.1.51

Category:EC 1.2.4
- Oxoglutarate dehydrogenase EC 1.2.4.2

Category:EC 1.3 (act on the CH-CH group of donors)

Category:EC 1.3.1 (with NAD⁺ or NADP⁺ as acceptor)
- Biliverdin reductase EC 1.3.1.24

Category:EC 1.3.2 (with a cytochrome as acceptor)

Category:EC 1.3.3 (with oxygen as acceptor)
- Protoporphyrinogen oxidase EC 1.3.3.4

Category:EC 1.3.5 (with a quinone or similar compound as acceptor)

Category:EC 1.3.7 (with an iron-sulfur protein as acceptor)

Category:EC 1.3.99 (with other acceptors)

Category:EC 1.4 (act on the CH-NH₂ group of donors)

Category:EC 1.4.3
- Monoamine oxidase EC 1.4.3.4

Category:EC 1.5 (act on CH-NH group of donors)

Category:EC 1.5.1 (with NAD⁺ or NADP⁺ as acceptor)
- Dihydrofolate reductase EC 1.5.1.3
- Methylenetetrahydrofolate reductase EC 1.5.1.20

Category:EC 1.5.3 (with oxygen as acceptor)
- Sarcosine oxidase EC 1.5.3.1
- Dihydrobenzophenanthridine oxidase EC 1.5.3.12

Category:EC 1.5.4 (with a disulfide as acceptor)

Category:EC 1.5.5 (with a quinone or similar compound as acceptor)

Category:EC 1.5.7 (with an iron-sulfur protein as acceptor)

Category:EC 1.5.8 (with a flavin as acceptor)

Category:EC 1.5.99 (with other acceptors)

Category:EC 1.6 (act on NADH or NADPH)

Category:EC 1.6.1 (with NAD⁺ or NADP⁺ as acceptor)

Category:EC 1.6.2 (with a cytochrome as acceptor)

Category:EC 1.6.3 (with oxygen as acceptor)

Category:EC 1.6.4 now Category:EC 1.8.1

Category:EC 1.6.5 (with a quinone or similar compound as acceptor)
- NADH dehydrogenase EC 1.6.5.3

Category:EC 1.6.6 (with a nitrogenous group as acceptor)

Category:EC 1.6.7 now Category:EC 1.18.1

Category:EC 1.6.8 now Category:EC 1.5.1

Category:EC 1.6.99 (with other acceptors)

Category:EC 1.7 (act on other nitrogenous compounds as donors)

Category:EC 1.7.1 (with NAD⁺ or NADP⁺ as acceptor)

Category:EC 1.7.2 (with a cytochrome as acceptor)

Category:EC 1.7.3 (with oxygen as acceptor)
- Urate oxidase EC 1.7.3.3

Category:EC 1.7.7 (with an iron-sulfur protein as acceptor)

Category:EC 1.7.99 (with other acceptors)
- Nitrite reductase EC 1.7.99.3
- Nitrate reductase EC 1.7.99.4

Category:EC 1.8 (act on a sulfur group of donors)

Category:EC 1.8.1 (with NAD⁺ or NADP⁺ as acceptor)
- Glutathione reductase EC 1.8.1.7
- Thioredoxin reductase EC 1.8.1.9

Category:EC 1.8.2 (with a cytochrome as acceptor)

Category:EC 1.8.3 (with oxygen as acceptor)
- Sulfite oxidase EC 1.8.3.1

Category:EC 1.8.4 (with a disulfide as acceptor)

Category:EC 1.8.5 (with a quinone or similar compound as acceptor)

Category:EC 1.8.6 deleted, included in EC 2.5.1.18

Category:EC 1.8.7 (with an iron-sulfur protein as acceptor)

Category:EC 1.8.98 (with other, known, acceptors)

Category:EC 1.8.99 (with other acceptors)

Category:EC 1.9 (act on a heme group of donors)

Category:EC 1.9.3 (with oxygen as acceptor)
- Cytochrome c oxidase EC 1.9.3.1

Category:EC 1.9.6 (with a nitrogenous as acceptor)

Category:EC 1.9.99 transferred, now EC 1.9.98.1

Category:EC 1.10 (act on diphenols and related substances as donors)

Category:EC 1.10.1(with NAD⁺ or NADP⁺ as acceptor)

Category:EC 1.10.2 (with a cytochrome as acceptor)
- Coenzyme Q - cytochrome c reductase EC 1.10.2.2

Category:EC 1.10.3 (with oxygen as acceptor)
- Catechol oxidase EC 1.10.3.1
- Laccase EC 1.10.3.2

Category:EC 1.10.99 (with other acceptors)

Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)

Category:EC 1.11.1 (peroxidases)
- Cytochrome c peroxidase EC 1.11.1.5
- Catalase EC 1.11.1.6
- Myeloperoxidase EC 1.11.1.7
- Thyroid peroxidase EC 1.11.1.8
- Glutathione peroxidase EC 1.11.1.9

Category:EC 1.12 (act on hydrogen as a donor)

Category:EC 1.12.1 (with NAD⁺ or NADP⁺ as acceptor)

Category:EC 1.12.2 (with a cytochrome as acceptor)

Category:EC 1.12.5 (with a quinone or similar compound as acceptor)

Category:EC 1.12.7 (with an iron-sulfur protein as acceptor)

Category:EC 1.12.98 (with other known acceptors)

Category:EC 1.12.99 (with other acceptors)

Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)

Category:EC 1.13.11 (With incorporation of two atoms of oxygen)
- 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27)

Category:EC 1.13.12 (With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases))
- Renilla-luciferin 2-monooxygenase EC 1.13.12.5
- Cypridina-luciferin 2-monooxygenase EC 1.13.12.6
- Firefly luciferase EC 1.13.12.7
- Watasenia-luciferin 2-monooxygenase EC 1.13.12.8
- Oplophorus-luciferin 2-monooxygenase EC 1.13.12.13

Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)

Cytochrome P450 oxidase

Category:Cytochrome P450
- Aromatase EC 1.14.14.1
- CYP2D6 EC 1.14.14.1
- CYP2E1 EC 1.14.14.1
- CYP3A4 EC 1.14.14.1
- Cytochrome P450 oxidase

Category:EC 1.14.12
- Nitric oxide dioxygenase

Category:EC 1.14.13
- Nitric oxide synthase EC 1.14.13.39

Category:EC 1.14.14
- Aromatase EC 1.14.14.1
- CYP2D6 EC 1.14.14.1
- CYP2E1 EC 1.14.14.1
- CYP3A4 EC 1.14.14.1

Category:EC 1.14.16
- Phenylalanine hydroxylase EC 1.14.16.1

Category:EC 1.14.18
- Tyrosinase EC 1.14.18.1

Category:EC 1.15 (act on superoxide radicals as acceptors)

Category:EC 1.15.1
- Superoxide dismutase EC 1.15.1.1

Category:EC 1.16 (oxidize metal ions)

Category:EC 1.16.3
- Ceruloplasmin EC 1.16.3.1

Category:EC 1.17 (act on CH or CH₂ groups)

Category:EC 1.17.1
- Leucoanthocyanidin reductase EC 1.17.1.3
- Xanthine dehydrogenase EC 1.17.1.4
- Nicotinate dehydrogenase EC 1.17.1.5
- 4-hydroxy-tetrahydrodipicolinate reductase EC 1.17.1.8

Category:EC 1.17.2
- Nicotinate dehydrogenase (cytochrome) EC 1.17.2.1

Category:EC 1.17.3
- Xanthine oxidase EC 1.17.3.2

Category:EC 1.17.4
- Ribonucleotide reductase EC 1.17.4.1
- Ribonucleoside-triphosphate reductase EC 1.17.4.2
- Vitamin K epoxide reductase
- Vitamin-K-epoxide reductase (warfarin-sensitive) EC 1.17.4.4
- Vitamin-K-epoxide reductase (warfarin-insensitive) EC 1.17.4.5
- RRM1
- RRM2
- RRM2B

Category:EC 1.17.5
- Caffeine dehydrogenase EC 1.17.5.2

Category:EC 1.17.7

Category:EC 1.17.99

Category:EC 1.18 (act on iron-sulfur proteins as donors)

Category:EC 1.18.6
- Nitrogenase EC 1.18.6.1

Category:EC 1.19 (act on reduced flavodoxin as donor)

Category:EC 1.19.6
- Nitrogenase (flavodoxin) EC 1.19.6.1

Category:EC 1.20 (act on phosphorus or arsenic as donors)

Category:EC 1.20.1

Category:EC 1.20.2

Category:EC 1.20.4
- Arsenate reductase (glutaredoxin) EC 1.20.4.1
- Glutaredoxin

Category:EC 1.20.9

Category:EC 1.20.99

Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)

Category:EC 1.21.1
- Iodotyrosine deiodinase EC 1.21.1.1

Category:EC 1.21.3
- Isopenicillin N synthase EC 1.21.3.1
- Tetrahydrocannabinolic acid synthase EC 1.21.3.7

Category:EC 1.21.4

Category:EC 1.21.99
- Thyroxine 5-deiodinase EC 1.21.99.3
- Iodothyronine deiodinase EC 1.21.99.3 and EC 1.21.99.4

Category:EC 1.97 (other oxidoreductases)

Category:EC 1.97.1
- Deiodinase EC 1.97.1.10

Category:Transferases (EC 2) (Transferase)

Glutathione S-transferase

Category:EC 2.1 (transfer one-carbon groups, Methylase)

Category:EC 2.1.1
- Catechol-O-methyl transferase EC 2.1.1.6
- DNA methyltransferase EC 2.1.1.72, EC 2.1.1.113, EC 2.1.1.37
- Histone methyltransferase EC 2.1.1.43, EC 2.1.1.125

Category:EC 2.1.3
- Aspartate transcarbamoylase EC 2.1.3.2
- Ornithine transcarbamoylase EC 2.1.3.3

Category:EC 2.2 (transfer aldehyde or ketone groups)

Category:EC 2.2.1
- Transketolase EC 2.2.1.1
- Transaldolase EC 2.2.1.2
- Acetolactate synthase EC 2.2.1.6
- 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase EC 2.2.1.9

Category:EC 2.3 (acyltransferases)

Category:EC 2.3.1
- Aminolevulinic acid synthase EC 2.3.1.37
- Choline acetyltransferase EC 2.3.1.6

Category:EC 2.3.2
- Factor XIII EC 2.3.2.13
- Gamma glutamyl transpeptidase EC 2.3.2.2
- Transglutaminase EC 2.3.2.13

Category:EC 2.4 (glycosyltransferases)

Category:EC 2.4.2
- Hypoxanthine-guanine phosphoribosyltransferase EC 2.4.2.8

Category:EC 2.5

Category:EC 2.5.1
- Thiaminase EC 2.5.1.2

Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)

- Flavin prenyltransferase EC 2.5.1.129

Category:EC 2.6 (transfer nitrogenous groups)

Category:EC 2.6.1
- Alanine transaminase EC 2.6.1.2
- Aspartate transaminase EC 2.6.1.1

Category:EC 2.7 (transfer phosphorus-containing groups)

Category:EC 2.7.2
- Butyrate kinase (EC 2.7.2.7)

Category:EC 2.8 (transfer sulfur-containing groups)

EC 2.8.1.1: Thiosulfate sulfurtransferase

EC 2.8.1.2: 3-mercaptopyruvate sulfurtransferase

EC 2.8.1.3: Thiosulfate--thiol sulfurtransferase

EC 2.8.1.4: tRNA uracil 4-sulfurtransferase

EC 2.8.1.5: Thiosulfate--dithiol sulfurtransferase

EC 2.8.1.6: Biotin synthase

EC 2.8.1.7: Cysteine desulfurase

EC 2.8.1.8: Lipoyl synthase

EC 2.8.1.9: Molybdenum cofactor sulfurtransferase

EC 2.8.1.10: Thiazole synthase

EC 2.8.1.11: Molybdopterin synthase sulfurtransferase

EC 2.8.1.12: Molybdopterin synthase

EC 2.8.1.13: tRNA-uridine 2-sulfurtransferase

EC 2.8.1.14: tRNA-5-taurinomethyluridine 2-sulfurtransferase

EC 2.8.1.15: tRNA-5-methyluridine(54) 2-sulfurtransferase

Category:EC 2.9 (transfer selenium-containing groups)

EC 2.9.1.1: L-seryl-tRNA(Sec) selenium transferase

EC 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase

Category:Hydrolases (EC 3) (Hydrolase)

Hydrolytic enzyme

Category:EC 3.1 (act on ester bonds)

Nuclease

Endonuclease

Exonuclease

Category:EC 3.1.1
- Acid hydrolase
- Phospholipase A (EC 3.1.1.4)
- Acetylcholinesterase (EC 3.1.1.7)
- Cholinesterase (EC 3.1.1.8)
- Lipoprotein lipase (EC 3.1.1.34)

Category:EC 3.1.2
- Ubiquitin carboxy-terminal hydrolase L1 (EC 3.1.2.15)

Category:EC 3.1.3
- Phosphatase
- Alkaline phosphatase (EC 3.1.3.1)
- Fructose bisphosphatase (EC 3.1.3.11)

Category:EC 3.1.4
- Phospholipase C (EC 3.1.4.3)
- CGMP specific phosphodiesterase type 5 (EC 3.1.4.17)
- Phospholipase D (EC 3.1.4.50)

Category:EC 3.1.21
- Restriction enzyme Type 1 (EC 3.1.21.3)
- Restriction enzyme Type 2 (EC 3.1.21.4)
- Restriction enzyme Type 3 (EC 3.1.21.5)
- Restriction enzyme Type 4 (?)
- Deoxyribonuclease I (EC 3.1.21.1)

Category:EC 3.1.26
- RNase H (EC 3.1.26.4)

Category:EC 3.1.27
- Ribonuclease

Category:EC 3.2 (act on sugars - glycosylases)

Category:EC 3.2.1
- Amylase (EC 3.2.1.1)
- Sucrase (EC 3.2.1.10)
- Chitinase (EC 3.2.1.14)
- Lysozyme (EC 3.2.1.17)
- Maltase (EC 3.2.1.20)
- Lactase (EC 3.2.1.23)
- Beta-galactosidase (EC 3.2.1.23)
- Hyaluronidase (EC 3.2.1.35)

Category:EC 3.3 (act on ether bonds)

Category:EC 3.3

Adenosylmethionine hydrolase

S-adenosyl-L-homocysteine hydrolase

Alkenylglycerophosphocholine hydrolase

Alkenylglycerophosphoethanolamine hydrolase

Cholesterol-5,6-oxide hydrolase

Hepoxilin-epoxide hydrolase

Isochorismatase

Leukotriene-A4 hydrolase

Limonene-1,2-epoxide hydrolase

Microsomal epoxide hydrolase

Trans-epoxysuccinate hydrolase

Category:EC 3.4 (act on peptide bonds - Peptidase)

Category:EC 3.4.11
- Alanine aminopeptidase

Category:EC 3.4.15
- Angiotensin converting enzyme

Category:EC 3.4.21
- Serine protease
- Chymotrypsin (EC 3.4.21.1)
- Trypsin (EC 3.4.21.4)
- Thrombin (EC 3.4.21.5)
- Factor X (EC 3.4.21.6)
- Plasmin (EC 3.4.21.7)
- Acrosin (EC 3.4.21.10)
- Factor VII (EC 3.4.21.21)
- Factor IX (EC 3.4.21.22)
- Prolyl oligopeptidase (EC 3.4.21.26)
- Factor XI (EC 3.4.21.27)
- Elastase (EC 3.4.21.37)
- Factor XII (EC 3.4.21.38)
- Proteinase K (EC 3.4.21.64)
- Tissue plasminogen activator (EC 3.4.21.68)
- Protein C (EC 3.4.21.69)

Category:EC 3.4.22
- Separase (EC 3.4.22.49)

Category:EC 3.4.23
- Pepsin (EC 3.4.23.1)
- Rennet (EC 3.4.23.4)
- Renin (EC 3.4.23.15)
- Trypsinogen (EC 3.4.23.18) and (20/21/23/24/26)
- Plasmepsin (EC 3.4.23.39)

Category:EC 3.4.24
- Matrix metalloproteinase (EC 3.4.24.7)

Category:EC 3.4.25
- Metalloendopeptidase

Category:EC 3.5 (act on carbon-nitrogen bonds, other than peptide bonds)

Category:EC 3.5.1 (In linear amides)
- Urease (EC 3.5.1.5)

Category:EC 3.5.2 (In cyclic amides)
- Beta-lactamase (EC 3.5.2.6)

Category:EC 3.5.3 (In linear amidines)
- Arginase (EC 3.5.3.1)

Category:EC 3.5.4 (In cyclic amidines)
- Adenosine deaminase (EC 3.5.4.4)
- GTP cyclohydrolase I (EC 3.5.4.16)

Category:EC 3.5.5 (In nitriles)
- Nitrilase (EC 3.5.5.1)

Category:EC 3.6 (act on acid anhydrides)

Category:EC 3.6.1
- Helicase
- DnaB helicase
- RecQ helicase

Category:EC 3.6.3
- ATPase
- NaKATPase (EC 3.6.3.9)
- ATP synthase (EC 3.6.3.14)

Category:EC 3.7 (act on carbon-carbon bonds)

Kynureninase EC 3.7.1.3

Category:EC 3.8 (act on halide bonds)

EC 3.8.1.3 Haloacetate dehalogenase

Category:EC 3.9 (act on phosphorus-nitrogen bonds)

EC 3.9.1.1: Phosphoamidase

EC 3.9.1.2: Protein arginine phosphatase

EC 3.9.1.3: Phosphohistidine phosphatase

Category:EC 3.10 (act on sulfur-nitrogen bonds)

EC 3.10.1.1: N-sulfoglucosamine sulfohydrolase

EC 3.10.1.2: Cyclamate sulfohydrolase

Category:EC 3.11 (act on carbon-phosphorus bonds)

EC 3.11.1.1: Phosphonoacetaldehyde hydrolase

EC 3.11.1.2: Phosphonoacetate hydrolase

EC 3.11.1.3: Phosphonopyruvate hydrolase

Category:EC 3.12 (act on sulfur-sulfur bonds)

EC 3.12.1.1: Trithionate hydrolase

Category:EC 3.13 (act on carbon-sulfur bonds)

EC 3.13.1.1: UDP-sulfoquinovose synthase

EC 3.13.1.3: 2'-hydroxybiphenyl-2-sulfinate desulfinase

EC 3.13.1.4: 3-sulfinopropanoyl-CoA desulfinase

EC 3.13.1.5: Carbon disulfide hydrolase

EC 3.13.1.6: [[[CysO sulfur-carrier protein]-S-L-cysteine hydrolase]]

EC 3.13.1.7: Carbonyl sulfide hydrolase

EC 3.13.1.8: S-adenosyl-L-methionine hydrolase (adenosine-forming)

Category:Lyases (EC 4) (Lyase)

Category:EC 4.1 (carbon-carbon lyases)

Category:EC 4.1.1
- Ornithine decarboxylase (EC 4.1.1.17)
- Uridine monophosphate synthetase (EC 4.1.1.23)
- Aromatic-L-amino-acid decarboxylase (EC 4.1.1.28)
- RubisCO (EC 4.1.1.39)

Category:EC 4.1.2
- Fructose-bisphosphate aldolase (EC 4.1.2.13)

Category:EC 4.2 (carbon-oxygen lyases)

Category:EC 4.2.1
- Carbonic anhydrase (EC 4.2.1.1)
- Tryptophan synthase (EC 4.2.1.20)

Category:EC 4.3 (carbon-nitrogen lyases)

Category:EC 4.3.1
- Phenylalanine ammonia-lyase (EC 4.3.1.24)

Category:EC 4.4 (carbon-sulfur lyases)

Category:EC 4.4.1
- Cystathionine gamma-lyase
- Cystathionine beta-lyase
- Leukotriene C4 synthase

Category:EC 4.5 (carbon-halide lyases)

Category:EC 4.5.1
- Dichloromethane dehalogenase
- Halohydrin dehalogenase

Category:EC 4.6 (phosphorus-oxygen lyases)

Category:EC 4.6.1
- Adenylate cyclase (EC 4.6.1.1)
- Guanylate cyclase (EC 4.6.1.2)

Category:Isomerases (EC 5) (Isomerase)

Category:EC 5.1 (racemases and epimerases)

Category:EC 5.1.1

Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)

Serine racemase

Category:EC 5.1.2

Mandelate racemase

Category:EC 5.1.3

UDP-glucose 4-epimerase

Category:EC 5.1.99

Methylmalonyl CoA epimerase

Category:EC 5.2 (cis-trans-isomerases)

Category:EC 5.2

FKBP: FKBP1A

FKBP1B

FKBP2

FKBP3

FKBP5

FKBP6

FKBP8

FKBP9

FKBP10

FKBP52

FKBPL

Cyclophilin

Parvulin

Prolyl isomerase

2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase

Beta-carotene isomerase

Farnesol 2-isomerase

Furylfuramide isomerase

Linoleate isomerase

Maleate isomerase

Maleylacetoacetate isomerase

Maleylpyruvate isomerase

Parvulin

Photoisomerase

Prolycopene isomerase

Prolyl isomerase

Retinal isomerase

Retinol isomerase

Zeta-carotene isomerase

Category:EC 5.3 (intramolecular oxidoreductases)

Category:EC 5.3.3
- Enoyl CoA isomerase (EC 5.3.3.8)

Category:EC 5.3.4
- Protein disulfide isomerase (EC 5.3.4.1)

Category:EC 5.4 (intramolecular transferases -- mutases)

Category:EC 5.4.2
- Phosphoglucomutase (EC 5.4.2.2)

Category:EC 5.5 (intramolecular lyases)

Intramolecular lyases:
EC number	Examples
EC 5.5.1.1	Muconate cycloisomerase
EC 5.5.1.2	3-carboxy-cis,cis-muconate cycloisomerase
EC 5.5.1.3	Tetrahydroxypteridine cycloisomerase
EC 5.5.1.4	Inositol-3-phosphate synthase
EC 5.5.1.5	Carboxy-cis,cis-muconate cyclase
EC 5.5.1.6	Chalcone isomerase
EC 5.5.1.7	Chloromuconate cycloisomerase
EC 5.5.1.8	(+)-bornyl diphosphate synthase
EC 5.5.1.9	Cycloeucalenol cycloisomerase
EC 5.5.1.10	Alpha-pinene-oxide decyclase
EC 5.5.1.11	Dichloromuconate cycloisomerase
EC 5.5.1.12	Copalyl diphosphate synthase
EC 5.5.1.13	Ent-copalyl diphosphate synthase
EC 5.5.1.14	Syn-copalyl-diphosphate synthase
EC 5.5.1.15	Terpentedienyl-diphosphate synthase
EC 5.5.1.16	Halimadienyl-diphosphate synthase
EC 5.5.1.17	(S)-beta-macrocarpene synthase
EC 5.5.1.18	Lycopene epsilon-cyclase
EC 5.5.1.19	Lycopene beta-cyclase
EC 5.5.1.20	Prosolanapyrone-III cycloisomerase
EC 5.5.1.n1	D-ribose pyranase
EC 5.5.1.22	Steroid Delta Isomerase

Category:EC 5.99 (other isomerases)

Category:EC 5.99.1
- Topoisomerase (type I: EC 5.99.1.2, type II: EC 5.99.1.3)

Category:Ligases (EC 6) (Ligase)

Category:EC 6.1 (form carbon-oxygen bonds)

6-carboxytetrahydropterin synthase

Category:EC 6.1.1
- FARSB (EC 6.1.1.20)

Category:EC 6.2 (form carbon-sulfur bonds)

EC 6.2.1.1: Acetate--CoA ligase

EC 6.2.1.2: Medium-chain acyl-CoA ligase

EC 6.2.1.3: Long-chain-fatty-acid--CoA ligase

EC 6.2.1.4: Succinate--CoA ligase (GDP-forming)

EC 6.2.1.5: Succinate--CoA ligase (ADP-forming)

EC 6.2.1.6: Glutarate--CoA ligase

EC 6.2.1.7: Cholate--CoA ligase

EC 6.2.1.8: Oxalate--CoA ligase

EC 6.2.1.9: Malate--CoA ligase

EC 6.2.1.10: Acid--CoA ligase (GDP-forming)

EC 6.2.1.11: Biotin--CoA ligase

EC 6.2.1.12: 4-coumarate--CoA ligase

EC 6.2.1.13: Acetate--CoA ligase (ADP-forming)

EC 6.2.1.14: 6-carboxyhexanoate--CoA ligase

EC 6.2.1.15: Arachidonate--CoA ligase

EC 6.2.1.16: Acetoacetate--CoA ligase

EC 6.2.1.17: Propionate--CoA ligase

EC 6.2.1.18: Citrate--CoA ligase

EC 6.2.1.19: Long-chain-fatty-acid--protein ligase

EC 6.2.1.20: [[Long-chain-fatty-acid--[acyl-carrier-protein] ligase]]

EC 6.2.1.21: Transferred entry: 6.2.1.30

EC 6.2.1.22: [[[Citrate (pro-3S)-lyase] ligase]]

EC 6.2.1.23: Dicarboxylate--CoA ligase

EC 6.2.1.24: Phytanate--CoA ligase

EC 6.2.1.25: Benzoate--CoA ligase

EC 6.2.1.26: o-succinylbenzoate--CoA ligase

EC 6.2.1.27: 4-hydroxybenzoate--CoA ligase

EC 6.2.1.28: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate--CoA ligase

EC 6.2.1.29: Transferred entry: 6.2.1.7

EC 6.2.1.30: Phenylacetate--CoA ligase

EC 6.2.1.31: 2-furoate--CoA ligase

EC 6.2.1.32: Anthranilate--CoA ligase

EC 6.2.1.33: 4-chlorobenzoate--CoA ligase

EC 6.2.1.34: Trans-feruloyl-CoA synthase

EC 6.2.1.35: [[Acetate--[acyl-carrier protein] ligase]]

EC 6.2.1.36: 3-hydroxypropionyl-CoA synthase

EC 6.2.1.37: 3-hydroxybenzoate--CoA ligase

EC 6.2.1.38: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase

EC 6.2.1.39: [[[Butirosin acyl-carrier protein]--L-glutamate ligase]]

EC 6.2.1.40: 4-hydroxybutyrate--CoA ligase

EC 6.2.1.41: 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate--CoA ligase

EC 6.2.1.42: 3-oxocholest-4-en-26-oate--CoA ligase

EC 6.2.1.43: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase

EC 6.2.1.44: 3-(methylthio)propionyl--CoA ligase

EC 6.2.1.45: E1 ubiquitin-activating enzyme

EC 6.2.1.46: [[L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase]]

EC 6.2.1.47: Medium-chain-fatty-acid--(acyl-carrier-protein) ligase

EC 6.2.1.48: Carnitine--CoA ligase

EC 6.2.1.49: Long-chain fatty acid adenylyltransferase FadD28

EC 6.2.1.50: 4-hydroxybenzoate adenylyltransferase FadD22

EC 6.2.1.51: 4-hydroxyphenylalkanoate adenylyltransferase FadD29

EC 6.2.1.52: L-firefly luciferin--CoA ligase

EC 6.2.1.53: [[L-proline--[L-prolyl-carrier protein] ligase]]

EC 6.2.1.54: [[D-alanine--[D-alanyl-carrier protein] ligase]]

EC 6.2.1.55: [[E1 SAMP-activating enzyme]

Category:EC 6.3 (form carbon-nitrogen bonds)

Glutamine synthetase (EC 6.3.1.2)

Argininosuccinate synthetase (EC 6.3.4.5)

CTP synthase (EC 6.3.4.2)

Category:EC 6.4 (form carbon-carbon bonds)

Pyruvate carboxylase (EC 6.4.1.1)

Acetyl-CoA carboxylase (EC 6.4.1.2)

Category:EC 6.5 (form phosphoric ester bonds)

DNA ligase (EC 6.5.1.1)

List of enzymes

Contents